3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol

Base Information

• Chemical Name: 3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol
• CAS No.: 1139688-46-2
• Molecular Formula: C₂₄H₁₇ClF₃NO₃
• Molecular Weight: 459.852

Synonyms:3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol

Chemical Property of 3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol

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Technology Process of 3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol

There total 1 articles about 3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]anisole (1139688-44-0) → 3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol (1139688-46-2)

Guidance literature:

3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]anisole; With boron tribromide; In dichloromethane; at 0 - 20 ℃;

With water; sodium hydrogencarbonate; sodium chloride; In dichloromethane; Saturated solution;

DOI:10.1021/jm900367w

Reference yield: 60.0%

Isobutyl (R)-lactate (61597-96-4,73523-02-1) + 3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol (1139688-46-2) → C31H29ClF3NO5 (1171817-31-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm900367w

Reference yield:

ethyl 1-bromocyclobutane-1-carboxylate (35120-18-4) + 3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenol (1139688-46-2) → C31H27ClF3NO5

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm900367w

upstream raw materials:

3-[[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]anisole

Downstream raw materials:

C₃₁H₂₉ClF₃NO₅

C₃₁H₂₉ClF₃NO₅

methyl (2R)-2-(3-{[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl}phenoxy)butanoate

methyl (2S)-2-(3-{[3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl}phenoxy)butanoate

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