4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide

Base Information

Chemical Name:4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide
CAS No.:1345880-25-2
Molecular Formula:C₂₃H₂₁NO₇S
Molecular Weight:455.488
Hs Code.:

Synonyms:4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide

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Chemical Property of 4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide

Chemical Property:

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Technology Process of 4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide

There total 5 articles about 4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.7%

: 1345882-21-4
5-(3-hydroxy-2,4-dimethoxyphenyl)-3H-isobenzofuran-1-one

: 40724-47-8
4-bromomethyl-benzenesulfonamide

: 1345880-25-2
4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 16h;

Reference yield:

: 64169-34-2
5-bromophthalide

: 1345880-25-2
4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 50 - 80 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 - 90 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 16 h / 80 °C

With potassium acetate; potassium carbonate; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 91-10-1
1,3-dimethoxy-2-hydroxy-benzene

: 1345880-25-2
4-[2,6-dimethoxy-3-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / tetrachloromethane / 1 h / -10 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 - 90 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 16 h / 80 °C

With bromine; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;