(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt

Base Information

• Chemical Name: (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt
• CAS No.: 1161573-31-4
• Molecular Formula: C₁₁H₁₃NO₃*C₁₇H₁₉ClN₂
• Molecular Weight: 494.033
• Mol file: 1161573-31-4.mol

Synonyms:(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt

Chemical Property of (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt

There total 2 articles about (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt (1161573-31-4)

Guidance literature:

In acetone; at 20 ℃; for 15h; Purification / work up; Heating / reflux;

Reference yield: 78.0%

(S)-2-acetylamino-3-phenylpropanoic acid (2018-61-3) + N-(4-chlorobenzhydryl)piperazine (303-26-4) → (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt (1161573-31-4) + 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine (439858-21-6)

Guidance literature:

In ethyl acetate; at 20 - 60 ℃; for 12h; Purification / work up;

Reference yield: 99.0%

(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt (1161573-31-4) → (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine (300543-56-0)

Guidance literature:

With sodium hydroxide; water; at 20 ℃; for 12.5h; Product distribution / selectivity;

upstream raw materials:

(S)-2-acetylamino-3-phenylpropanoic acid

N-(4-chlorobenzhydryl)piperazine

Downstream raw materials:

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine