2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Base Information

Chemical Name:2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile
CAS No.:156496-75-2
Molecular Formula:C₂₄H₂₂ClN₃O
Molecular Weight:403.911
Hs Code.:
European Community (EC) Number:648-228-5
Nikkaji Number:J583.294B

Synonyms:156496-75-2;2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile;AKOS024407938;1-Phenyl-2-amino-4-(4-chlorophenyl)-5-oxo-7,7-dimethyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile;2-amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile

Suppliers and Price of 2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Chemical Property:

XLogP3:5.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:403.1451400
Heavy Atom Count:29
Complexity:788

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CC2=C(C(C(=C(N2C3=CC=CC=C3)N)C#N)C4=CC=C(C=C4)Cl)C(=O)C1)C

Technology Process of 2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

There total 5 articles about 2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18940-21-1
5,5-dimethyl-3-(phenylamino)cyclohex-2-en-1-one

: 104-88-1
4-chlorobenzaldehyde

: 109-77-3
malononitrile

: 156496-75-2
2-amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In water; for 2h; Heating;
DOI:10.1016/j.tet.2008.06.061

Reference yield: 93.0%

: 1867-38-5
4-chlorobenzylidenemalonodinitrile

: 18940-21-1
5,5-dimethyl-3-(phenylamino)cyclohex-2-en-1-one

: 156496-75-2
2-amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Guidance literature:: N-benzyl-N,N,N-triethylammonium chloride; In water; for 10h; Heating;
DOI:10.1002/jccs.200700149

Reference yield: 92.0%

: 104-88-1
4-chlorobenzaldehyde

: 126-81-8
dimedone

: 62-53-3
aniline

: 109-77-3
malononitrile

: 156496-75-2
2-amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Guidance literature:: With Cu(OAc)₂-decorated bis-salicylaldehydetriazine-functionalized silica-coated manganese ferrite nanoparticles; In ethanol; at 20 ℃; for 0.25h; Green chemistry;
DOI:10.1002/aoc.5822