N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide

Base Information

• Chemical Name: N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide
• CAS No.: 1620951-84-9
• Molecular Formula: C₂₇H₂₇N₅O₃
• Molecular Weight: 469.543
• Mol file: 1620951-84-9.mol

Synonyms:N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide

Chemical Property of N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide

There total 11 articles about N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C28H27N3O4 (1620955-27-2) → N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide (1620951-84-9)

Guidance literature:

With hydrazine hydrate; at 100 ℃; for 3h;

Reference yield:

ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate (191338-94-0) → N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide (1620951-84-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide; water / ethanol / 2 h / Reflux

1.2: 16 h

2.1: methanol; diethyl ether / 1 h / 0 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; toluene / 14 h / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

6.1: hydrazine hydrate / 3 h / 100 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; hydrazine hydrate; triethylamine; cesium fluoride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; toluene;

Reference yield:

4-bromo-phenol (106-41-2) → N-(2-((4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)isobutyramide (1620951-84-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

2.2: 12 h / 65 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; toluene / 14 h / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

6.1: hydrazine hydrate / 3 h / 100 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; caesium carbonate; hydrazine hydrate; triethylamine; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

4-bromo-phenol

2-(4-bromophenyl)-1,6-naphthyridine-4-carboxylic acid