2-(1,3-Dioxolan-2-yl)-6-fluorobenzaldehyde

Base Information

Chemical Name:2-(1,3-Dioxolan-2-yl)-6-fluorobenzaldehyde
CAS No.:146137-73-7
Molecular Formula:C₁₀H₉FO₃
Molecular Weight:196.178
Hs Code.:
DSSTox Substance ID:DTXSID701265171

Synonyms:2-(1,3-dioxolan-2-yl)-6-fluorobenzaldehyde;146137-73-7;Benzaldehyde, 2-(1,3-dioxolan-2-yl)-6-fluoro-;SCHEMBL9431365;DTXSID701265171;CS-0368803;A1-76872

Suppliers and Price of 2-(1,3-Dioxolan-2-yl)-6-fluorobenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1,3-Dioxolan-2-yl)-6-fluorobenzaldehyde

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:196.05357231
Heavy Atom Count:14
Complexity:204

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COC(O1)C2=C(C(=CC=C2)F)C=O

Technology Process of 2-(1,3-Dioxolan-2-yl)-6-fluorobenzaldehyde

There total 5 articles about 2-(1,3-Dioxolan-2-yl)-6-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 109-72-8,29786-93-4
n-butyllithium

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 136835-12-6
2-(3-fluorophenyl)-1,3-dioxolane

: 146137-73-7
6-(1,3-dioxolan-2-yl)-6-fluorobenzaldehyde

Guidance literature:: In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;

Reference yield: 66.0%

: 136835-12-6
2-(3-fluorophenyl)-1,3-dioxolane

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 146137-73-7
6-(1,3-dioxolan-2-yl)-6-fluorobenzaldehyde

Guidance literature:: 2-(3-fluorophenyl)-1,3-dioxolane; With n-butyllithium; In tetrahydrofuran; at -78 - -40 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1515/hc-2012-0079

Reference yield:

: 2-(2-bromo-3-fluorophenyl)-1,3-dioxolane

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 146137-73-7
6-(1,3-dioxolan-2-yl)-6-fluorobenzaldehyde

Guidance literature:: 2-(2-bromo-3-fluorophenyl)-1,3-dioxolane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.tet.2017.11.035