(R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide

Base Information

• Chemical Name: (R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide
• CAS No.: 1093393-93-1
• Molecular Formula: C₁₄H₁₅BrF₃NOS
• Molecular Weight: 382.244
• Mol file: 1093393-93-1.mol

Synonyms:(R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide

Chemical Property of (R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide

There total 1 articles about (R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(R)-2-methylpropane-2-sulfinamide (196929-78-9) + (E)-4-(4-bromophenyl)-1,1,1-trifluoro-3-buten-2-one (366014-14-4) → (R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide (1093393-93-1)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1039/b810459j

Reference yield: 96.0%

(R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide (1093393-93-1) → (Rs,R)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-yl)-tert-butanesulfinamide (1093393-72-6)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1039/b810459j

Reference yield: 93.0%

(R,E)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-ylidene)-tert-butanesulfinamide (1093393-93-1) → (Rs,S)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-yl)-tert-butanesulfinamide (1093393-73-7)

Guidance literature:

With L-Selectride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1039/b810459j

upstream raw materials:

(R)-2-methylpropane-2-sulfinamide

(E)-4-(4-bromophenyl)-1,1,1-trifluoro-3-buten-2-one

Downstream raw materials:

(Rs,R)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-yl)-tert-butanesulfinamide

(Rs,S)-N-((E)-4-(4-bromophenyl)-1,1,1-trifluorobut-3-en-2-yl)-tert-butanesulfinamide