1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone

Base Information

Chemical Name:1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone
CAS No.:1253936-85-4
Molecular Formula:C₂₄H₂₆N₆O
Molecular Weight:414.51
Hs Code.:

Synonyms:1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone

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Chemical Property of 1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone

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Technology Process of 1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone

There total 6 articles about 1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253382-59-0
N-(2-amino-phenyl)-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-benzamide

: 1253936-85-4
1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone

Guidance literature:: toluene-4-sulfonic acid; In 1,1-dichloroethane; at 130 - 160 ℃; for 0.833333h; microwave irradiation;

Reference yield:

: 1253382-56-7
2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-benzoic acid methyl ester

: 1253936-85-4
1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C

1.2: pH 4

2.1: oxalyl dichloride / dichloromethane / 4 °C / Inert atmosphere

2.2: 4 - 20 °C

2.3: 4 - 20 °C

3.1: toluene-4-sulfonic acid / 1,1-dichloroethane / 0.83 h / 130 - 160 °C / microwave irradiation

With oxalyl dichloride; water; sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,1-dichloroethane; dichloromethane;

Reference yield:

: 446831-27-2
2-(piperazin-1-yl)benzoic acid

: 1253936-85-4
1-{4-[2-(1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}-2-(3,5-dimethyl-pyrazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 30 h / 20 °C / Reflux

1.2: ion exchange column

2.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C

3.2: pH 4

4.1: oxalyl dichloride / dichloromethane / 4 °C / Inert atmosphere

4.2: 4 - 20 °C

4.3: 4 - 20 °C

5.1: toluene-4-sulfonic acid / 1,1-dichloroethane / 0.83 h / 130 - 160 °C / microwave irradiation

With oxalyl dichloride; sulfuric acid; water; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide;