methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Base Information

Chemical Name:methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate
CAS No.:1426133-59-6
Molecular Formula:C₂₂H₂₀N₆O₄
Molecular Weight:433.431
Hs Code.:

Synonyms:methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

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Chemical Property of methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

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Technology Process of methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

There total 9 articles about methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426135-85-4
methyl 3-(3-(3-(7-bromoimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

: 1426133-59-6
methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Guidance literature:: With sodium borodeuteride; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 65 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1426135-82-1
methyl 3-(3-(3-amino-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

: 1426133-59-6
methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 0.5 h / 0 - 20 °C / Inert atmosphere

2: sodium borodeuteride; palladium diacetate; triphenylphosphine; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

With pyridine; sodium borodeuteride; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 939-79-7
4-cyano-2-nitrotoluene

: 1426133-59-6
methyl 3-(3-(3-(7-deuteroimidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / ethanol / 3 h / 78 °C

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.2 h / 115 °C / Microwave irradiation

3.1: hydrogenchloride / acetonitrile; 1,4-dioxane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.42 h / 20 °C

5.1: tin(II) chloride dihdyrate / ethanol / 3 h / 78 °C

5.2: Saturated solution

6.1: pyridine / 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: sodium borodeuteride; palladium diacetate; triphenylphosphine; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium borodeuteride; tin(II) chloride dihdyrate; N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; palladium diacetate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; acetonitrile;