1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide

Base Information

• Chemical Name: 1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide
• CAS No.: 1352009-65-4
• Molecular Formula: C₁₈H₂₄N₂O₂
• Molecular Weight: 300.401
• Mol file: 1352009-65-4.mol

Synonyms:1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide

Chemical Property of 1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide

There total 1 articles about 1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-acetyl-N-o-tolylcyclopentanecarboxamide + N,N-dimethylacetamide dimethyl acetal (18871-66-4) → 1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide (1352009-65-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 - 85 ℃; for 5.08333h; Reflux;

DOI:10.1021/ol203124f

Reference yield: 87.0%

1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide (1352009-65-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6,10-dioxo-7-o-tolyl-7-azaspiro[4.5]dec-8-ene-9-carbaldehyde (1352009-87-0)

Guidance literature:

N,N-dimethyl-formamide; With trifluoromethylsulfonic anhydride; Cooling with ice;

1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide; at 100 ℃; for 0.5h;

DOI:10.1021/ol203124f

Reference yield: 71.0%

1-[3-(dimethylamino)acryloyl]-N-o-tolylcyclopentanecarboxamide (1352009-65-4) → 3-[(dimethylamino)methylene]-1-(o-tolylimino)-2-oxaspiro[4.4]nonan-4-one

Guidance literature:

With [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃;

DOI:10.1021/acs.orglett.5b02485

upstream raw materials:

N,N-dimethylacetamide dimethyl acetal

Downstream raw materials:

6,10-dioxo-7-o-tolyl-7-azaspiro[4.5]dec-8-ene-9-carbaldehyde