methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate

Base Information

Chemical Name:methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate
CAS No.:907611-30-7
Molecular Formula:C₂₂H₂₈N₂O₂
Molecular Weight:352.477
Hs Code.:

Synonyms:methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate

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Chemical Property of methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate

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Technology Process of methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate

There total 4 articles about methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 907611-21-6
2-(3,3-dimethylbutanoyl)-3-(4-methylphenyl)acrylonitrile

: 30414-53-0
methyl propanoyl acetate

: 907611-30-7
methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate

Guidance literature:: In acetic acid; at 80 ℃; for 0.05h;

Reference yield:

: 96798-17-3
5,5-dimethyl-3-oxohexanenitrile

: 907611-30-7
methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; acetic acid / toluene / 8 h / Reflux

2: acetic acid / 6 h / 80 °C

With piperidine; acetic acid; In toluene; 1: Knoevenagel condensation;
DOI:10.1021/jm101236h

Reference yield:

: 10250-48-3
methyl 3,3-dimethylbutyrate

: 907611-30-7
methyl 5-cyano-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 70 °C

2: piperidine; acetic acid / toluene / 8 h / Reflux

3: acetic acid / 6 h / 80 °C

With piperidine; sodium hydride; acetic acid; In tetrahydrofuran; toluene; mineral oil; 2: Knoevenagel condensation;
DOI:10.1021/jm101236h