N₆-(3-amino-propyl)-N₄-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine

Base Information

• Chemical Name: N₆-(3-amino-propyl)-N₄-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine
• CAS No.: 936549-01-8
• Molecular Formula: C₂₄H₃₀BrFN₆O
• Molecular Weight: 517.444

Synonyms:N₆-(3-amino-propyl)-N₄-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine

Chemical Property of N₆-(3-amino-propyl)-N₄-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine

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Technology Process of N₆-(3-amino-propyl)-N₄-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine

There total 1 articles about N₆-(3-amino-propyl)-N₄-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-{3-[4-(4-bromo-2-fluoro-phenylamino)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-6-ylamino]-propyl}-isoindol-1,3-dione (936549-00-7) → N6-(3-amino-propyl)-N4-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine (936549-01-8)

Guidance literature:

With ethanol; hydrazine; for 1h; Heating / reflux;

Reference yield: 54.0%

N6-(3-amino-propyl)-N4-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine (936549-01-8) + acryloyl chloride (814-68-6,25189-84-8) → N-{3-[4-(4-bromo-2-fluoro-phenylamino)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-6-ylamino]-propyl}-acrylamide

Guidance literature:

N₆-(3-amino-propyl)-N₄-(4-bromo-2-fluoro-phenyl)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-4,6-diamine; With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 0.166667h;

acryloyl chloride; In water; ethyl acetate; at 0 - 20 ℃; for 0.666667h;

upstream raw materials:

2-{3-[4-(4-bromo-2-fluoro-phenylamino)-7-(1-methyl-piperidin-4-ylmethoxy)-quinazolin-6-ylamino]-propyl}-isoindol-1,3-dione

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