Technology Process of 4H-Isoxazolo[3,4-c]azepin-3-ol,5,6,7,8-tetrahydro-(9CI)
There total 4 articles about 4H-Isoxazolo[3,4-c]azepin-3-ol,5,6,7,8-tetrahydro-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
at 25 ℃;
for 4h;
DOI:10.1021/jm00152a010
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / 10percent Pd/C / ethanol; H2O / 2205.2 Torr
2: triethylamine / tetrahydrofuran / 2 h / 0 °C
3: 1.) boron trifluoride etherate, 2.) hydroxyammonium chloride, NaOH / 1.) ether, from -70 deg C to -60 deg C, 30 min, 2) EtOH, water, 0 deg C, 90 min
4: 41 percent / HCl / ethyl acetate / 4 h / 25 °C
With
hydrogenchloride; sodium hydroxide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1021/jm00152a010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / tetrahydrofuran / 2 h / 0 °C
2: 1.) boron trifluoride etherate, 2.) hydroxyammonium chloride, NaOH / 1.) ether, from -70 deg C to -60 deg C, 30 min, 2) EtOH, water, 0 deg C, 90 min
3: 41 percent / HCl / ethyl acetate / 4 h / 25 °C
With
hydrogenchloride; sodium hydroxide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; triethylamine;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm00152a010
