(Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

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Chemical Name:(Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
CAS No.:1341220-50-5
Molecular Formula:C₁₇H₁₅N₅O₂
Molecular Weight:321.338
Hs Code.:

Synonyms:(Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

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Chemical Property of (Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

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Technology Process of (Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

There total 4 articles about (Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1341220-64-1
(Z)-4-(2-(methylthio)-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

: 1341220-50-5
(Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 90 ℃; for 24h; Sealed tube;
DOI:10.1016/j.bmc.2011.12.054

Reference yield:

: 934353-34-1
2-phenyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

: 1341220-50-5
(Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 0.5 h / 0 °C

1.2: 14.25 h / 0 - 20 °C

2.1: ammonium hydroxide / tetrahydrofuran / 24 h / 90 °C / Sealed tube

With ammonium hydroxide; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.12.054

Reference yield:

: 98-80-6
phenylboronic acid

: 1341220-50-5
(Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-phenyl-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 18 h / 95 °C

2.1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 0.5 h / 0 °C

2.2: 14.25 h / 0 - 20 °C

3.1: ammonium hydroxide / tetrahydrofuran / 24 h / 90 °C / Sealed tube

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; sodium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.12.054