Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester
CAS No.:256342-02-6
Molecular Formula:C₄₀H₄₈O₁₂
Molecular Weight:720.814
Hs Code.:

Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

Synonyms:Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

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Chemical Property of Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

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Technology Process of Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

There total 18 articles about Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256341-93-2
(2R,3S,4R,5R,6R)-4-Benzyloxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2,3-diol

: 256341-87-4
Benzoic acid (3R,4R,5S)-4,5-bis-allyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yl ester

: 256342-02-6
Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

Guidance literature:: (2R,3S,4R,5R,6R)-4-Benzyloxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2,3-diol; With di(n-butyl)tin oxide; In methanol; at 90 ℃; for 3h;

Benzoic acid (3R,4R,5S)-4,5-bis-allyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yl ester; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 25 ℃; for 8h;

With methanol; pyridinium p-toluenesulfonate; at 25 ℃; for 1h;
DOI:10.1002/(SICI)1521-3773(19991115)38:22<3340::AID-ANIE3340>3.0.CO;2-2

Reference yield:

: Trifluoro-methanesulfonate2-[(1R,2R,3S)-2,3-bis-allyloxy-1-benzoyloxy-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-3-methyl-thiazol-3-ium;

: 256342-02-6
Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaBH₄ / methanol / 0.5 h / 0 °C

1.2: H₂O; CuCl₂; CuO / acetonitrile / 2 h / 25 °C

2.1: 10.97 g / TBAF; AcOH / 2 h / 25 °C

3.1: 85 percent / DBU / CH₂Cl₂ / 0.5 h / 0 °C

4.1: nBu₂SnO / methanol / 3 h / Heating

4.2: TMSOTf / CH₂Cl₂ / 12 h / 0 - 25 °C

4.3: 10.82 g / PPTS; MeOH / 1 h / 25 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; di(n-butyl)tin oxide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; 1.1: Reduction / 1.2: Ring cleavage / 2.1: Cyclization / 3.1: Addition / 4.1: Cyclization / 4.2: Ring cleavage / 4.3: Methanolysis;
DOI:10.1002/1521-3765(20000901)6:17<3116::AID-CHEM3116>3.0.CO;2-8

Reference yield:

: 306726-12-5
Benzoic acid (1R,2R,3S)-2,3-bis-allyloxy-4-(tert-butyl-diphenyl-silanyloxy)-1-thiazol-2-yl-butyl ester

: 256342-02-6
Benzoic acid (2S,3R,4R,5S)-4,5-bis-allyloxy-2-[(2S,3S,4R,5R,6R)-4-benzyloxy-3-hydroxy-5-(4-methoxy-benzyloxy)-6-methoxymethyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: molecular sieves 4 Angstroem / acetonitrile / 0.25 h / 25 °C

2.1: NaBH₄ / methanol / 0.5 h / 0 °C

2.2: H₂O; CuCl₂; CuO / acetonitrile / 2 h / 25 °C

3.1: 10.97 g / TBAF; AcOH / 2 h / 25 °C

4.1: 85 percent / DBU / CH₂Cl₂ / 0.5 h / 0 °C

5.1: nBu₂SnO / methanol / 3 h / Heating

5.2: TMSOTf / CH₂Cl₂ / 12 h / 0 - 25 °C

5.3: 10.82 g / PPTS; MeOH / 1 h / 25 °C

With sodium tetrahydroborate; 4 A molecular sieve; tetrabutyl ammonium fluoride; di(n-butyl)tin oxide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; acetonitrile; 1.1: Methylation / 2.1: Reduction / 2.2: Ring cleavage / 3.1: Cyclization / 4.1: Addition / 5.1: Cyclization / 5.2: Ring cleavage / 5.3: Methanolysis;
DOI:10.1002/1521-3765(20000901)6:17<3116::AID-CHEM3116>3.0.CO;2-8