N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide

Base Information

Chemical Name:N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide
CAS No.:1441144-56-4
Molecular Formula:C₂₆H₁₉Cl₂F₃N₄O₃S
Molecular Weight:595.429
Hs Code.:

Synonyms:N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide

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Chemical Property of N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide

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Technology Process of N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide

There total 6 articles about N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441142-91-1
N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(chloromethyl)benzamide

: 60-24-2
2-hydroxyethanethiol

: 1441144-56-4
N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide

Guidance literature:: With potassium carbonate; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1441141-76-9
1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole

: 1441144-56-4
N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

3.1: manganese(IV) oxide / tetrahydrofuran; 1,2-dichloro-ethane / 1 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; 1,2-dichloro-ethane / 5 h / 70 °C

5.1: potassium carbonate; N,N-dimethyl-formamide / 20 °C

With manganese(IV) oxide; N-iodo-succinimide; isopropylmagnesium chloride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield:

: 445-01-2
5-bromo-2-chlorobenzotrifluoride

: 1441144-56-4
N-[5-chloro-3-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-2-pyridyl]-3-(2-hydroxyethylsulfanylmethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; sodium carbonate; sodium L-ascorbate / dimethyl sulfoxide / 52 h / 100 - 140 °C / Inert atmosphere

2.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -78 °C

3.2: 2 h / -78 °C

4.1: manganese(IV) oxide / tetrahydrofuran; 1,2-dichloro-ethane / 1 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; 1,2-dichloro-ethane / 5 h / 70 °C

6.1: potassium carbonate; N,N-dimethyl-formamide / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; manganese(IV) oxide; N-iodo-succinimide; copper(l) iodide; isopropylmagnesium chloride; sodium carbonate; potassium carbonate; acetic acid; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane;