1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea

Base Information

Chemical Name:1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea
CAS No.:1609932-46-8
Molecular Formula:C₂₈H₂₄F₃N₅O₂
Molecular Weight:519.526
Hs Code.:

Synonyms:1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea

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Chemical Property of 1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea

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Technology Process of 1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea

There total 15 articles about 1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1609932-72-0
tert-butyl 4-(7-(4-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperidine-1-carboxylate

: 1609932-46-8
1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 3-methoxyquinoxaline-6-carbaldehyde

: 1609932-46-8
1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 11 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: manganese(IV) oxide / dichloromethane / 50 °C

3.1: hydrogenchloride / water; methanol / 0 - 20 °C

4.1: thionyl chloride / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 60 °C / Inert atmosphere

6.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 760.05 Torr

7.1: manganese(IV) oxide / dichloromethane / 50 °C

8.1: hydrogenchloride / acetic acid; water / 4 h / 110 °C

9.1: triethylamine / methanol / 1 h / 20 °C

10.1: dmap / tetrahydrofuran / 3 h / 70 °C

11.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; dmap; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; acetonitrile;

Reference yield:

: 1196-57-2
quinoxalin-2⁽¹⁾-one

: 1609932-46-8
1-(4-(3-(piperidin-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(3-(trifiuoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 15 steps

1.1: bromine / acetic acid / 20 °C

2.1: trichlorophosphate; N,N-dimethyl-formamide / 2 h / 120 °C

3.1: potassium carbonate / 2 h / Reflux

4.1: triethylamine; triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 12 h / 90 °C / 7500.75 Torr / Autoclave

5.1: n-butyllithium / tetrahydrofuran / -78 °C

5.2: -78 °C

6.1: manganese(IV) oxide / dichloromethane / 50 °C

7.1: hydrogenchloride / water; methanol / 0 - 20 °C

8.1: thionyl chloride / Reflux

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 60 °C / Inert atmosphere

10.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 760.05 Torr

11.1: manganese(IV) oxide / dichloromethane / 50 °C

12.1: hydrogenchloride / acetic acid; water / 4 h / 110 °C

13.1: triethylamine / methanol / 1 h / 20 °C

14.1: dmap / tetrahydrofuran / 3 h / 70 °C

15.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; triethylsilane; dmap; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; bromine; sodium carbonate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;