3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid

Base Information

Chemical Name:3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid
CAS No.:1256944-65-6
Molecular Formula:C₂₇H₂₈F₃NO₂
Molecular Weight:455.52
Hs Code.:

Synonyms:3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid

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Chemical Property of 3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid

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Technology Process of 3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid

There total 6 articles about 3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256944-61-2
3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid methyl ester

: 1256944-65-6
3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid

Guidance literature:: 3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid methyl ester; With water; lithium hydroxide; In methanol; for 4h;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 1351478-38-0
2-trifluoromethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde

: 1256944-65-6
3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

3.1: lithium hydroxide / [(1,4-hydroquinone)-rhodium(COD)]BF₄ / 1,2-dimethoxyethane; water / 50 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

5.1: water; lithium hydroxide / methanol / 4 h

5.2: pH 5

With water; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; lithium hydroxide; palladium on activated charcoal; [(1,4-hydroquinone)-rhodium(COD)]BF₄; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1256944-58-7
3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl]acrylic acid methyl ester

: 1256944-65-6
3-{4-[(1S,3R)-3-((R)-1-naphthalen-1-yl-ethylamino)-cyclopentyl]-2-trifluoromethyl-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

2.1: lithium hydroxide / [(1,4-hydroquinone)-rhodium(COD)]BF₄ / 1,2-dimethoxyethane; water / 50 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

4.1: water; lithium hydroxide / methanol / 4 h

4.2: pH 5

With water; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; lithium hydroxide; palladium on activated charcoal; [(1,4-hydroquinone)-rhodium(COD)]BF₄; In methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;