2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide

Base Information

Chemical Name:2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide
CAS No.:1357079-53-8
Molecular Formula:C₂₀H₂₂FN₅O
Molecular Weight:367.426
Hs Code.:

Synonyms:2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide

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Chemical Property of 2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide

Chemical Property:

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Technology Process of 2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide

There total 9 articles about 2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₅FN₆O₅S

: 1357079-53-8
2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide

Guidance literature:: C₂₆H₂₅FN₆O₅S; With caesium carbonate; In acetonitrile; for 0.166667h;

With thiophenol; In acetonitrile; at 20 ℃; for 10h;
DOI:10.1021/acs.jmedchem.1c01087

Reference yield:

: 325152-98-5,179811-61-1
(S)-2-amino-2-(3-fluorophenyl)ethan-1-ol

: 1357079-53-8
2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; tert-butyl alcohol / 4 h / 75 °C

2.1: thionyl chloride; pyridine / acetonitrile / -40 - 20 °C

2.2: 18 h / 20 °C

3.1: caesium carbonate / acetonitrile / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

5.1: ammonia / methanol / 70 °C

6.1: caesium carbonate / acetonitrile / 0.17 h

6.2: 10 h / 20 °C

With pyridine; thionyl chloride; ammonia; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/acs.jmedchem.1c01087

Reference yield:

: 1035490-58-4
[(S)-1-(3-fluoro-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

: 1357079-53-8
2-ethyl-4-[(S)-1-(3-fluoro-phenyl)-2-methylamino-ethylamino]-quinazoline-8-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride; pyridine / acetonitrile / -40 - 20 °C

1.2: 18 h / 20 °C

2.1: caesium carbonate / acetonitrile / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

4.1: ammonia / methanol / 70 °C

5.1: caesium carbonate / acetonitrile / 0.17 h

5.2: 10 h / 20 °C

With pyridine; thionyl chloride; ammonia; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/acs.jmedchem.1c01087