(4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: (4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester
• CAS No.: 1203604-67-4
• Molecular Formula: C₂₅H₂₈N₆O₃S
• Molecular Weight: 492.602
• Mol file: 1203604-67-4.mol

Synonyms:(4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester

Chemical Property of (4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester

There total 5 articles about (4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

[4-(3-chloro-[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamic acid tert-butyl ester (1203605-36-0) + (5-methoxybenzothiazol-2-yl)methylamine hydrogen chloride (1204196-92-8) → (4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester (1203604-67-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 - 80 ℃; Inert atmosphere;

DOI:10.1021/jm301499r

Reference yield: 81.0%

→ (4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester (1203604-67-4)

Guidance literature:

Reference yield:

5-methoxybenzothiazole-2-carboxaldehyde (854059-90-8) → (4-{3-[(5-methoxybenzothiazol-2-ylmethyl)amino][1,2,4]triazin-5-yl}-3,5-dimethylphenyl)carbamic acid tert-butyl ester (1203604-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 80 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; acetonitrile;

DOI:10.1021/jm301499r

upstream raw materials:

5-methoxybenzothiazole-2-carboxaldehyde

5-methoxy-1,3-benzothiazole-2-carbaldehyde oxime

[4-(3-chloro-[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamic acid tert-butyl ester

(5-methoxybenzothiazol-2-yl)methylamine hydrogen chloride

Downstream raw materials:

[5-(4-amino-2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

C₂₄H₂₉N₇OS