3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid

Base Information

Chemical Name:3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid
CAS No.:1428639-94-4
Molecular Formula:C₂₁H₁₅FO₅
Molecular Weight:366.346
Hs Code.:

Synonyms:3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid

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Chemical Property of 3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid

Chemical Property:

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Technology Process of 3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid

There total 11 articles about 3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428639-93-3
methyl 3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylate

: 1428639-94-4
3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 70 ℃; for 3h;

Reference yield:

: 1428639-86-4
methyl 2'-fluoro-5-nitrobiphenyl-2-carboxylate

: 1428639-94-4
3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: iron; acetic acid / 2 h / 85 °C

2: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

3: potassium carbonate / acetone / 4 h / Reflux

4: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

5: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

6: water; sodium hydroxide / ethanol / 3 h / 70 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; iron; potassium carbonate; acetic acid; sodium hydroxide; sodium nitrite; In ethanol; dichloromethane; acetone; 4: |Sonogashira Cross-Coupling;

Reference yield:

: 1428639-87-5
methyl 5-amino-2'-fluorobiphenyl-2-carboxylate

: 1428639-94-4
3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

2: potassium carbonate / acetone / 4 h / Reflux

3: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

4: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

5: water; sodium hydroxide / ethanol / 3 h / 70 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; potassium carbonate; sodium hydroxide; sodium nitrite; In ethanol; dichloromethane; acetone; 3: |Sonogashira Cross-Coupling;