methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate

Base Information

• Chemical Name: methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate
• CAS No.: 1234056-14-4
• Molecular Formula: C₁₈H₂₁N₃O₄
• Molecular Weight: 343.382
• Mol file: 1234056-14-4.mol

Synonyms:methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate

Chemical Property of methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate

There total 7 articles about methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate (1092566-65-8) → methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate (1234056-14-4)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen; water / Raney nickel / methanol / 18 h / 20 °C / 760.05 Torr

2: sodium methylate / methanol / 1.17 h / 60 °C

3: water; sulfuric acid / 4 h / Reflux

4: thionyl chloride / 6 h / 80 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With thionyl chloride; di-isopropyl azodicarboxylate; sulfuric acid; water; hydrogen; sodium methylate; triphenylphosphine; Raney nickel; In tetrahydrofuran; methanol;

Reference yield:

3-(5-methyl-[1,2,4]-oxadiazol-3-yl)benzoic acid (264264-32-6) → methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate (1234056-14-4)

Guidance literature:

Multi-step reaction with 6 steps

1: sulfuric acid / 18 h / Reflux

2: hydrogen; water / Raney nickel / methanol / 18 h / 20 °C / 760.05 Torr

3: sodium methylate / methanol / 1.17 h / 60 °C

4: water; sulfuric acid / 4 h / Reflux

5: thionyl chloride / 6 h / 80 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With thionyl chloride; di-isopropyl azodicarboxylate; sulfuric acid; water; hydrogen; sodium methylate; triphenylphosphine; Raney nickel; In tetrahydrofuran; methanol;

Reference yield:

3-Cyanobenzoic acid (1877-72-1) → methyl 3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzoate (1234056-14-4)

Guidance literature:

Multi-step reaction with 8 steps

1: potassium carbonate; hydroxylamine hydrochloride / methanol / 15 h / 40 °C / Reflux

2: acetic anhydride; acetic acid / water / 14 h / 118 °C

3: sulfuric acid / 18 h / Reflux

4: hydrogen; water / Raney nickel / methanol / 18 h / 20 °C / 760.05 Torr

5: sodium methylate / methanol / 1.17 h / 60 °C

6: water; sulfuric acid / 4 h / Reflux

7: thionyl chloride / 6 h / 80 °C

8: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With thionyl chloride; di-isopropyl azodicarboxylate; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; sodium methylate; acetic anhydride; potassium carbonate; acetic acid; triphenylphosphine; Raney nickel; In tetrahydrofuran; methanol; water;

upstream raw materials:

methyl 3-[5-(dimethylaminomethyleneamino)pyrimidin-2-yl]benzoate

methyl 3-carbamimidoylbenzoate acetic acid

3-Cyanobenzoic acid

methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate

Downstream raw materials:

{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]phenyl}methanol