methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside

Base Information

• Chemical Name: methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside
• CAS No.: 77988-11-5
• Molecular Formula: C₄₀H₄₀O₆
• Molecular Weight: 616.754
• Mol file: 77988-11-5.mol

Synonyms:methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside

Chemical Property of methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside

There total 1 articles about methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

benzyl chloride (100-44-7) + methyl 6-O-trityl-α-D-glucopyranoside (18311-26-7) → methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside (77988-11-5)

Guidance literature:

With potassium hydroxide; at 95 ℃; for 2h;

Reference yield: 83.0%

methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside (77988-11-5) → methyl 2,4-di-O-benzyl-α-D-glucopyranoside (58341-67-6)

Guidance literature:

With sulfonic acid; In 1,4-dioxane; at 85 ℃; for 1h;

Reference yield: 64.0%

methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside (77988-11-5) + ethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside (32934-24-0,41670-79-5,52645-73-5,55722-49-1,79389-52-9,99031-86-4,125354-48-5,126187-25-5) → methyl O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1 → 3)-2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside

Guidance literature:

methyl 2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside; ethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside; In 1,2-dichloro-ethane; at 20 ℃; for 16h; Molecular sieve; Inert atmosphere;

With methyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

DOI:10.1021/acs.joc.6b02151

upstream raw materials:

benzyl chloride

methyl 6-O-trityl-α-D-glucopyranoside

Downstream raw materials:

methyl 3-O-acetyl-2,4-di-O-benzyl-6-O-triphenylmethyl-α-D-glucopyranoside

methyl 2,4-di-O-benzyl-α-D-glucopyranoside

methyl-O-acetyl-2,4-di-O-benzyl-α-D-glucopyranoside