(2R,3R)-3-(N-Boc-amino)-1-oxirane-4-phenylbutane

Base Information

• Chemical Name: (2R,3R)-3-(N-Boc-amino)-1-oxirane-4-phenylbutane
• CAS No.: 98818-34-9
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 98818-34-9.mol

Synonyms:Carbamicacid, (1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R*,R*)-(?à)-; Carbamic acid,(1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R*,R*)-

Chemical Property of (2R,3R)-3-(N-Boc-amino)-1-oxirane-4-phenylbutane

Chemical Property:

• PSA: 50.86000
• LogP: 2.91210

Purity/Quality:

97% ^*data from raw suppliers

(2R,3R)-3-(N-BOC-Amino)-1-oxirane-4-phenylbutane 98 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3R)-3-(N-Boc-amino)-1-oxirane-4-phenylbutane

There total 68 articles about (2R,3R)-3-(N-Boc-amino)-1-oxirane-4-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2S,3S)-3-(tert-butoxycarbonyl)amino-4-phenyl-1-tosyloxy-2-butanol (149451-81-0) → (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2)

Guidance literature:

With potassium carbonate; In methanol; at 0 - 20 ℃;

DOI:10.1016/j.tetasy.2009.08.001

Reference yield: 93.0%

(2S,3S)-1-bromo-3-<(tert-butoxycarbonyl)amino>-4-phenyl-2-butanol (136630-87-0) → (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 1h; Ambient temperature;

DOI:10.1016/00404-0399(50)1087X-

Reference yield: 87.0%

isopropyl alcohol (67-63-0,8013-70-5) + tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate (165727-45-7) + citric acid (77-92-9,906507-37-7) → (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2)

Guidance literature:

With sodium hydroxide; In water;

upstream raw materials:

methylenedimethyl sulfurane

Boc-L-phenylalaninal

((S)-1-benzylallyl)carbamic acid tert-butyl ester

tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate

Downstream raw materials:

(2R,3S,1'R)-3-(t-Boc-amino)-2-hydroxy-4-phenyl-1-<(1-phenylethyl)amino>butane

[(1S,2R)-1-Benzyl-3-((S)-1-tert-butylcarbamoyl-2-phenyl-ethylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

N-<1-phenyl-2(S)-<(tert-butoxycarbonyl)amino>-3(R)-hydroxybutan-4-yl>-L-phenylalanine (2(R)-hydroxy-1(S)-indanyl)amide

[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

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