Quinoxaline, 2,3-diethynyl-

Base Information

• Chemical Name: Quinoxaline, 2,3-diethynyl-
• CAS No.: 98813-72-0
• Molecular Formula: C12H6 N2
• Molecular Weight: 178.193
• Hs Code.: 2933990090
• Mol file: 98813-72-0.mol

Synonyms:Quinoxaline, 2,3-diethynyl-

Chemical Property of Quinoxaline, 2,3-diethynyl-

Chemical Property:

• PSA: 25.78000
• LogP: 1.59240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoxaline, 2,3-diethynyl-

There total 6 articles about Quinoxaline, 2,3-diethynyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3-Bis-[(triisopropylsilanyl)-ethynyl]-quinoxaline (199275-08-6) → 2,3-diethynylquinoxaline (98813-72-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; at -78 ℃; for 0.0833333h;

DOI:10.1016/S0040-4020(97)01007-7

Reference yield: 78.0%

2,3-dichloroquinoxaline (2213-63-0) + trimethylsilylacetylene (1066-54-2) → 2,3-diethynylquinoxaline (98813-72-0)

Guidance literature:

2,3-dichloroquinoxaline; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 0.333333h; Inert atmosphere;

trimethylsilylacetylene; at 50 - 55 ℃; for 24h; Inert atmosphere;

With potassium fluoride dihydrate; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2018.01.046

Reference yield: 65.0%

2,3-bis(3-hydroxy-3-methylbut-1-ynyl)quinoxaline (98813-62-8) → 2,3-diethynylquinoxaline (98813-72-0)

Guidance literature:

With sodium hydroxide; In toluene; for 2h; Heating;

upstream raw materials:

2,3-bis(3-hydroxy-3-methylbut-1-ynyl)quinoxaline

2,3-Bis-[(triisopropylsilanyl)-ethynyl]-quinoxaline

2,3-dichloroquinoxaline

1,6-bis-(tri-iso-propylsilyl)-hexa-1,5-diyne-3,4-dione

Downstream raw materials:

Phenazin

Refernces

• 1、 Kim, Chang-Sik,Russell. "Rapid Bergman cyclization of 1,2-diethynylheteroarenes". . p. 8229 - 8234. Retrieved 2007/10/03.
• 2、 Ames, Donald E.,Mitchell, John C.,Takundwa, Chisango C.. "Preparation and Reactions of 2-Alkynyl-3-chloroquinoxalines.". . p. 1683 - 1696. Retrieved 2007/10/02.