Technology Process of 1-(4'-Bromo-biphenyl-4-yl)-2-(6-propyl-spiro[3.3]hept-2-yl)-ethanone
There total 14 articles about 1-(4'-Bromo-biphenyl-4-yl)-2-(6-propyl-spiro[3.3]hept-2-yl)-ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: pyridine
2: NaH / dioxane
3: 1.) LiAlH4; 2.) dil HCl / 1.) ether
4: pyridine
5: NaH / dioxane
6: 1.) KOH / 1.) EtOH, H2O; 2.) reflux
7: thionyl chloride
8: lithium aluminum hydride / diethyl ether / 2 h / Heating
9: pyridine
10: 71 percent / dimethylsulfoxide / 1.5 h / 130 °C
11: 1.) KOH; 2.) 18percent HCl / 1.) water/ethanol, reflux, 24 h; 2.) water, 0 deg C
12: thionyl chloride / 2 h / Heating
13: aluminum chloride / various solvent(s) / 16 h / Ambient temperature
With
pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; sodium hydride;
In
1,4-dioxane; diethyl ether; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 1.) LiAlH4; 2.) dil HCl / 1.) ether
2: pyridine
3: NaH / dioxane
4: 1.) KOH / 1.) EtOH, H2O; 2.) reflux
5: thionyl chloride
6: lithium aluminum hydride / diethyl ether / 2 h / Heating
7: pyridine
8: 71 percent / dimethylsulfoxide / 1.5 h / 130 °C
9: 1.) KOH; 2.) 18percent HCl / 1.) water/ethanol, reflux, 24 h; 2.) water, 0 deg C
10: thionyl chloride / 2 h / Heating
11: aluminum chloride / various solvent(s) / 16 h / Ambient temperature
With
pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; sodium hydride;
In
1,4-dioxane; diethyl ether; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 12 steps
1: NaH / dioxane
2: 1.) LiAlH4; 2.) dil HCl / 1.) ether
3: pyridine
4: NaH / dioxane
5: 1.) KOH / 1.) EtOH, H2O; 2.) reflux
6: thionyl chloride
7: lithium aluminum hydride / diethyl ether / 2 h / Heating
8: pyridine
9: 71 percent / dimethylsulfoxide / 1.5 h / 130 °C
10: 1.) KOH; 2.) 18percent HCl / 1.) water/ethanol, reflux, 24 h; 2.) water, 0 deg C
11: thionyl chloride / 2 h / Heating
12: aluminum chloride / various solvent(s) / 16 h / Ambient temperature
With
pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; sodium hydride;
In
1,4-dioxane; diethyl ether; dimethyl sulfoxide;
