4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester
• CAS No.: 273376-94-6
• Molecular Formula: C₂₇H₃₃FN₄O₆
• Molecular Weight: 528.581

Synonyms:4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester

Chemical Property of 4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester

There total 2 articles about 4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methyl azide (239438-48-3) → 4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester (273376-94-6)

Guidance literature:

With hydrogen; Lindlar's catalyst; In methanol; at 20 ℃; for 4h; under 760 Torr;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine (198410-25-2) → 4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester (273376-94-6)

Guidance literature:

With ammonia; In tetrahydrofuran; at 20 ℃; for 18h; Cooling with ice;

Reference yield:

4-{4-[5-(tert-butoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester (273376-94-6) → C19H27FN4O4 (273376-95-7)

Guidance literature:

With hydrogen; palladium/active carbon; In ethanol; for 3h; under 1551.49 Torr;

upstream raw materials:

di-tert-butyl dicarbonate

(R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methyl azide

(S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine

Downstream raw materials:

C₁₉H₂₇FN₄O₄

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