ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

Base Information

Chemical Name:ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate
CAS No.:221165-52-2
Molecular Formula:C₂₆H₂₃F₃N₆O₆
Molecular Weight:572.5
Hs Code.:

ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

Synonyms:ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

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Chemical Property of ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

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Technology Process of ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

There total 13 articles about ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 3-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-4-trifluoromethyl-1,2-phenylenediamine

: 609-09-6
Diethyl ketomalonate

: 221165-52-2
ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

Guidance literature:: In ethanol; for 5h; Heating / reflux;

Reference yield:

: 221165-54-4
ethyl 3,4-dihydro-7-(4-formylimidazol-1-yl)-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate

: 221165-52-2
ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; NaOAc / ethanol / 4 h / Heating

2: 556 mg / hydrogen; HCl / Pd/C / ethanol / 2 h / 20 °C / 3040 Torr

3: Et₃N / dimethylformamide / 5 h / 60 °C

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.08.060

Reference yield:

: 7-[4-(hydroxyimino-methyl)-imidazol-1-yl]-3-oxo-6-trifluoromethyl-3,4-dihydro-quinoxaline-2-carboxylic acid ethyl ester

: 221165-52-2
ethyl 3,4-dihydro-7-(4-(((4-ethoxycarbonylphenyl)aminocarbonylamino)methyl)imidazole-1-yl)-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 556 mg / hydrogen; HCl / Pd/C / ethanol / 2 h / 20 °C / 3040 Torr

2: Et₃N / dimethylformamide / 5 h / 60 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.08.060