(S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Name:(S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester
CAS No.:1025798-99-5
Molecular Formula:C₄₂H₆₈N₆O₈
Molecular Weight:785.037
Hs Code.:

(S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

Synonyms:(S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Property of (S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

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Technology Process of (S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

There total 13 articles about (S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175548-82-0
N-Fmoc-Ile-Phe-Ser(Bu^t)-Pro-Ile-Pro-OBu^t

: 1025798-99-5
(S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: With diethylamine; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1021/jo951986b

Reference yield:

: 71989-23-6,251316-98-0
Fmoc-Ile-OH

: 1025798-99-5
(S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 72 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

2: Et₂NH / acetonitrile / 2 h / Ambient temperature

3: 76 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

4: Et₂NH / acetonitrile / 2 h / Ambient temperature

5: 80 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

6: Et₂NH / acetonitrile / 2 h / Ambient temperature

7: 90 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

8: Et₂NH / acetonitrile / 2 h / Ambient temperature

9: 65 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

10: Et₂NH / acetonitrile / 2 h / Ambient temperature

With diethyl cyanophosphonate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951986b

Reference yield:

: 71989-31-6
Fmoc-Pro-OH

: 1025798-99-5
(S)-1-{(2S,3S)-2-[((S)-1-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-tert-butoxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

2: Et₂NH / acetonitrile / 2 h / Ambient temperature

3: 80 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

4: Et₂NH / acetonitrile / 2 h / Ambient temperature

5: 90 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

6: Et₂NH / acetonitrile / 2 h / Ambient temperature

7: 65 percent / EtN(i-Pr)2, diethyl phosphorocyanidate / CH₂Cl₂ / 4 h / -10 - -5 °C

8: Et₂NH / acetonitrile / 2 h / Ambient temperature

With diethyl cyanophosphonate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951986b