Technology Process of 10-Phenyl-5H-dibenzo
azepine
There total 7 articles about 10-Phenyl-5H-dibenzoazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
10-bromo-trifluoroacetyl-dibenz[b,f]azepine; phenylboronic acid;
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,2-dimethoxyethane; water;
Schlenk technique;
Glovebox;
Reflux;
Inert atmosphere;
With
sodium hydroxide;
In
methanol; 1,2-dimethoxyethane; water;
for 3h;
Schlenk technique;
Glovebox;
Reflux;
Inert atmosphere;
DOI:10.1021/acs.organomet.6b00879
- Guidance literature:
-
11-phenyl-1,2,3,4,5,11a-hexahydro-4aH-dibenzo[b,f]azepine-4a-carbonitrile;
With
tert.-butylhydroperoxide; water; oxygen; trifluoroacetic acid;
In
dimethyl sulfoxide;
at 110 ℃;
for 8h;
Sealed tube;
With
sodium hydrogencarbonate;
In
water; dimethyl sulfoxide;
at 20 ℃;
DOI:10.1002/adsc.201800865
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / hexane; tetrahydrofuran / 16 h / -70 °C
2: 75 percent / H2 / 10percent Pd/C / ethyl acetate; ethanol / 16 h / 750.06 Torr / Heating
3: NEt3 / CH2Cl2 / a) 0 deg C, 15 min, b) 25 deg C, 2 h
4: 0.70 g / KOtBu / dimethylsulfoxide
With
potassium tert-butylate; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate;
![10-bromo-trifluoroacetyl-dibenz[b,f]azepine](/Databaselist/images/loading.webp)
