3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 928653-75-2
• Molecular Formula: C8H7 I N2 O
• Molecular Weight: 274.06
• Mol file: 928653-75-2.mol

Synonyms:3-Iodo-4-methoxy-7-azaindole

Chemical Property of 3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

• Melting Point: 220-221掳C
• Refractive Index: 1.727
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 37.91000
• Density: 1.941g/cm³
• LogP: 2.17610
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine

There total 2 articles about 3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl 3-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (1254926-83-4) + C9H16NO4Zn(1+)*I(1-) → 3-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine (928653-75-2)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2018.03.037

Reference yield: 80.0%

4-methoxy-1H-pyrrolo<2,3-b>pyridine (122379-63-9) → 3-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine (928653-75-2)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/c1ob05586k

Reference yield:

3-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine (928653-75-2) + p-toluenesulfonyl chloride (98-59-9) → 3-iodo-4-methoxy-1-tosyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

DOI:10.1055/s-0040-1707818

upstream raw materials:

4-methoxy-1H-pyrrolo<2,3-b>pyridine

tert-butyl 3-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Downstream raw materials:

3-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridine

C₂₂H₂₃N₅O₃

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