Technology Process of 4-[3-(cyanomethylene)azetidin-1-yl]-N-isopropylbenzamide
There total 5 articles about 4-[3-(cyanomethylene)azetidin-1-yl]-N-isopropylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 1.17 h / -78 °C
1.2: 1.5 h / -78 °C
2.1: potassium tert-butylate / tetrahydrofuran / 1.17 h / -6 - 20 °C
2.2: 3.17 h / -6 - 20 °C
With
oxalyl dichloride; potassium tert-butylate;
dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
2.1: oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 1.17 h / -78 °C
2.2: 1.5 h / -78 °C
3.1: potassium tert-butylate / tetrahydrofuran / 1.17 h / -6 - 20 °C
3.2: 3.17 h / -6 - 20 °C
With
oxalyl dichloride; potassium tert-butylate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 40 °C
1.2: pH 7
2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
3.1: oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 1.17 h / -78 °C
3.2: 1.5 h / -78 °C
4.1: potassium tert-butylate / tetrahydrofuran / 1.17 h / -6 - 20 °C
4.2: 3.17 h / -6 - 20 °C
With
oxalyl dichloride; lithium hydroxide monohydrate; potassium tert-butylate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
dimethyl sulfoxide;
In
tetrahydrofuran; methanol; dichloromethane;
