7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid

Base Information

Chemical Name:7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid
CAS No.:1411982-70-1
Molecular Formula:C₂₆H₃₂FN₃O₄S
Molecular Weight:501.622
Hs Code.:

Synonyms:7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid

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Chemical Property of 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid

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Technology Process of 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid

There total 14 articles about 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411982-78-9
methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylate

: 1411982-70-1
7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid

Guidance literature:: methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylate; With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 110 ℃; for 1.25h; microwave irradiation;

With formic acid; In 1,4-dioxane; methanol; water; pH=4 - 5;

Reference yield:

: 316141-37-4
(R)-2-ethynyl-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester

: 1411982-70-1
7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere

1.2: -30 - -10 °C

2.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

4.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 100 °C / Inert atmosphere

7.1: sulfuric acid / methanol / 100 h / 20 °C / Reflux

8.1: pyridine / dichloromethane / 2 h / 20 °C

9.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 1 h / 95 °C / Inert atmosphere

10.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 1.25 h / 110 °C / microwave irradiation

10.2: pH 4 - 5

With pyridine; N-Bromosuccinimide; n-butyllithium; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen; caesium carbonate; trifluoroacetic acid; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 64241-01-6
methyl 2-amino-6-hydroxybenzoate

: 1411982-70-1
7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water

2.1: pyridine / dichloromethane / 1 h / Cooling with ice

3.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

5.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

7.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 100 °C / Inert atmosphere

8.1: sulfuric acid / methanol / 100 h / 20 °C / Reflux

9.1: pyridine / dichloromethane / 2 h / 20 °C

10.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 1 h / 95 °C / Inert atmosphere

11.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 1.25 h / 110 °C / microwave irradiation

11.2: pH 4 - 5

With pyridine; N-Bromosuccinimide; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen; sodium hydrogencarbonate; caesium carbonate; trifluoroacetic acid; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;