(4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone

Base Information

Chemical Name:(4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone
CAS No.:1259286-25-3
Molecular Formula:C₂₅H₃₁NO₃Si
Molecular Weight:421.612
Hs Code.:

Synonyms:(4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone

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Technology Process of (4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone

There total 1 articles about (4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 884589-74-6
(2'R,4S)-4-benzyl-3-[2'-methylpent-4'-ynyloyl]oxazolidin-2-oneR

: 1631-70-5
benzyldimethylsilane

: 1259286-25-3
(4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: With Pt(DVDS)(Pt-Bu₃); In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; at 1 - 3 ℃; Inert atmosphere;
DOI:10.1021/jo101790z

Reference yield: 96.0%

: 1259286-25-3
(4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone

: 616-38-6
carbonic acid dimethyl ester

: 1259286-26-4
(R,E)-methyl 5-(benzyldimethylsilyl)-2-methylpent-4-enoate

Guidance literature:: With sodium methylate; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1021/jo101790z

Reference yield:

: 1259286-25-3
(4S)-3-[(2R,4E)-5-(benzyldimethylsilyl)-2-methyl-1-oxo-4-penten-1-yl]-4-(phenylmethyl)-2-oxazolidinone

: 1190409-90-5
methyl (2S,3S,4Z)-1-(4-methylphenylsulfonyl)-2-methoxycarbonyl-4-[(2E,5R)-5-methoxycarbonyl-1-methyl-2-hexen-1-ylidene]-3-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / dichloromethane / 7 h / 20 °C / Inert atmosphere

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; naphthalene; tetrabutyl ammonium fluoride / tetrahydrofuran; water / 8 h / 20 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; naphthalene; tetrabutyl ammonium fluoride; sodium methylate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo101790z