N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide
CAS No.:953066-90-5
Molecular Formula:C₂₁H₁₄ClF₂N₃O₂S
Molecular Weight:445.877
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

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Chemical Property of N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

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Technology Process of N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

There total 6 articles about N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20582-55-2
ethyl 4-methylthiazole-5-carboxylate

: 953066-90-5
N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

2: phosphorus tribromide / dichloromethane / 1 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 20 °C

4: N,N-dimethyl-formamide / 3 h / 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 953070-83-2
8-fluoro-2-oxo-1,2-dihydroquinoline-4-carbonyl chloride

: 953070-80-9
3-Chloro-4-fluoro-N-((4-methylthiazol-5-yl)methyl)aniline

: 953066-90-5
N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 953066-90-5
N-(3-chloro-4-fluorophenyl)-8-fluoro-N-((4-methylthiazol-5-yl)methyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / toluene / 2 h / 20 °C

1.2: 3 h / Heating / reflux

2.1: sulfuryl dichloride / 3 h / Heating / reflux

3.1: N,N-dimethyl-formamide / 3 h / 20 °C

With sulfuryl dichloride; sodium hydride; In N,N-dimethyl-formamide; toluene;