(S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:(S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt
CAS No.:1283141-96-7
Molecular Formula:C₂HF₃O₂*C₁₈H₁₈FNO₃
Molecular Weight:429.368
Hs Code.:

Synonyms:(S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Suppliers and Price of (S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

There total 5 articles about (S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1283145-64-1
(S)-ethyl 2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetate

: 76-05-1
trifluoroacetic acid

: 1283141-96-7
(S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: (S)-ethyl 2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetate; With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1283141-96-7
(S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: zinc / acetic acid / 20 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 130 °C

4: sodium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C

With sodium hydrogencarbonate; caesium carbonate; sodium hydroxide; zinc; In tetrahydrofuran; methanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 1478-03-1
1-(2-fluorophenoxy)-4-nitrobenzene

: 1283141-96-7
(S)-2-(1-(4-(2-fluorophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: zinc / acetic acid / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 130 °C

3: sodium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C

With sodium hydrogencarbonate; sodium hydroxide; zinc; In tetrahydrofuran; methanol; water; acetic acid; ethyl acetate;
DOI:10.1021/acs.jmedchem.6b01559