6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

Base Information

Chemical Name:6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid
CAS No.:346694-21-1
Molecular Formula:C₄₅H₇₀O₁₂
Molecular Weight:803.044
Hs Code.:

6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

Synonyms:6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

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Chemical Property of 6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

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Technology Process of 6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

There total 5 articles about 6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 346694-33-5
7-O-benzyl-25-O-methyl-25-formylmonensin methyl ester

: 346694-21-1
6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In water; tert-butyl alcohol; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(01)00154-5

Reference yield:

: 116278-62-7
25-O-methylmonensin methyl ester

: 346694-21-1
6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / imidazole / tetrahydrofuran / 22 h / 20 °C

2: 57 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / 20 °C

3: 99 percent / TBAF*3H₂O / tetrahydrofuran / 4 h / 20 °C

4: 84 percent / pyridinium dichromate; molecular sieves 4A; Celite / CH₂Cl₂ / 4.5 h / 20 °C

5: 97 percent / NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; dipyridinium dichromate; 4 A molecular sieve; Celite; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)00154-5

Reference yield:

: 244088-32-2
25-O-methyl-26-O-t-butyldimethylsilylmonensin methyl ester

: 346694-21-1
6-{5'-[9-benzyloxy-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-2'-ethyl-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / 20 °C

2: 99 percent / TBAF*3H₂O / tetrahydrofuran / 4 h / 20 °C

3: 84 percent / pyridinium dichromate; molecular sieves 4A; Celite / CH₂Cl₂ / 4.5 h / 20 °C

4: 97 percent / NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; dipyridinium dichromate; 4 A molecular sieve; Celite; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)00154-5