(2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

Base Information

Chemical Name:(2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone
CAS No.:1431302-71-4
Molecular Formula:C₁₆H₃₀O₂Si
Molecular Weight:282.498
Hs Code.:

Synonyms:(2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

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Technology Process of (2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

There total 3 articles about (2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 288264-99-3,7086-80-8
(2R,5S)-2-hydroxy-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

: 69739-34-0
t-butyldimethylsiyl triflate

: 1431302-71-4
(2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol400754e

Reference yield:

: 203719-53-3
(-)-limonene oxide

: 1431302-71-4
(2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / aq. phosphate buffer / 32 h / 20 °C / pH 3.1

2: 2-iodoxybenzoic acid / ethyl acetate / 16 h / Reflux

3: 2,6-dimethylpyridine / dichloromethane / -78 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; potassium phosphate; 2-iodoxybenzoic acid; In aq. phosphate buffer; dichloromethane; ethyl acetate;
DOI:10.1021/ol400754e

Reference yield:

: 59121-82-3
(1R,2R,4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexane-1,2-diol

: 1431302-71-4
(2R,5S)-2-((tert-butyldimethylsilyl)oxy)-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 2-iodoxybenzoic acid / ethyl acetate / 16 h / Reflux

2: 2,6-dimethylpyridine / dichloromethane / -78 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; 2-iodoxybenzoic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/ol400754e