N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide

Base Information

Chemical Name:N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide
CAS No.:1048953-53-2
Molecular Formula:C₂₀H₁₄F₄N₄O₆
Molecular Weight:482.348
Hs Code.:

Synonyms:N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide

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Chemical Property of N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide

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Technology Process of N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide

There total 6 articles about N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 20142-88-5
2-(4-nitrophenoxy)acetyl chloride

: 1048953-79-2
3-(3-amino-4-fluorophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 1048953-53-2
N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide

Guidance literature:: With triethylamine; In toluene; at 0 - 20 ℃;
DOI:10.1002/cjoc.201180410

Reference yield:

: 1357510-83-8
3-(4-fluorophenyl-3-nitrophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 1048953-53-2
N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; acetic acid

2: triethylamine / toluene / 0 - 20 °C

With iron; acetic acid; triethylamine; In toluene;
DOI:10.1002/cjoc.201180410

Reference yield:

: 50844-60-5
3-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidine-2,4-(1H,3H)-dione

: 1048953-53-2
N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)-2-(4-nitrophenoxy)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: sulfuric acid; nitric acid

3: iron; acetic acid

4: triethylamine / toluene / 0 - 20 °C

With sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/cjoc.201180410