C₁₈H₁₉F₃N₂O

Base Information

Chemical Name:C₁₈H₁₉F₃N₂O
CAS No.:1200496-80-5
Molecular Formula:C₁₈H₁₉F₃N₂O
Molecular Weight:336.357
Hs Code.:

C<sub>18</sub>H<sub>19</sub>F<sub>3</sub>N<sub>2</sub>O

Synonyms:C₁₈H₁₉F₃N₂O

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₁₉F₃N₂O

Chemical Property:

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Technology Process of C₁₈H₁₉F₃N₂O

There total 6 articles about C₁₈H₁₉F₃N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200496-78-1
C₂₀H₂₁F₃N₂O₂

: 1200496-80-5
C₁₈H₁₉F₃N₂O

Guidance literature:: C₂₀H₂₁F₃N₂O₂; With hydrogenchloride; water; In ethanol; at 90 ℃; for 5h;

With sodium hydroxide; In ethanol;

Reference yield:

: 434-45-7
2,2,2-Trifluoroacetophenone

: 1200496-80-5
C₁₈H₁₉F₃N₂O

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid; sulfuric acid / 2 h / -25 - -15 °C

2.1: hydrogenchloride; water; iron / methanol / Cooling with ice

2.2: Cooling with ice

3.1: ethyl acetate / 2 h / 20 °C

4.1: pyridinium p-toluenesulfonate / toluene / 10 h / 130 °C / Dean-Stark apparatus

5.1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

6.1: hydrogenchloride; water / ethanol / 5 h / 90 °C

With hydrogenchloride; sulfuric acid; water; nitric acid; iron; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; ethanol; ethyl acetate; toluene;

Reference yield:

: 23516-80-5
3-amino-α,α,α-trifluoroacetophenone

: 1200496-80-5
C₁₈H₁₉F₃N₂O

Guidance literature:: Multi-step reaction with 4 steps

1: ethyl acetate / 2 h / 20 °C

2: pyridinium p-toluenesulfonate / toluene / 10 h / 130 °C / Dean-Stark apparatus

3: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

4: hydrogenchloride; water / ethanol / 5 h / 90 °C

With hydrogenchloride; water; pyridinium p-toluenesulfonate; In tetrahydrofuran; ethanol; ethyl acetate; toluene;