(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

Base Information

Chemical Name:(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate
CAS No.:1423324-26-8
Molecular Formula:C₃₀H₃₃N₉O₈
Molecular Weight:647.648
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

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Chemical Property of (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

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Technology Process of (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

There total 4 articles about (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423324-25-7
(S)-methyl 2-((S)-2-amino-5-methoxy-5-oxopentanamido)pent-4-ynoate trifluoroacetate

: 1046806-28-3
N²,N,N-dimethylaminomethylene-10-formyl-pteroic acid

: 1423324-26-8
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

Guidance literature:: N²,N,N-dimethylaminomethylene-10-formyl-pteroic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

(S)-methyl 2-((S)-2-amino-5-methoxy-5-oxopentanamido)pent-4-ynoate trifluoroacetate; With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1423324-23-5
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

: 1423324-26-8
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 5 h / 20 °C

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 °C

2.2: 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 14406-17-8
N-(tert-butoxycarbonyl)glutamic acid α-methyl ester dicyclohexylammonium salt

: 1423324-26-8
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)-amino)-5-methoxy-5-oxopentanamido)pent-4-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 0 - 20 °C

2: dichloromethane / 5 h / 20 °C

3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.bioconjchem.5b00644