N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

Base Information

Chemical Name:N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide
CAS No.:1609389-52-7
Molecular Formula:C₂₄H₂₃N₅OS
Molecular Weight:429.546
Hs Code.:

Synonyms:N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

Suppliers and Price of N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
ACY-957 99.91%
50mg
$ 1600.00

Total 5 raw suppliers

Chemical Property of N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

Chemical Property:

Boiling Point:602.7±55.0 °C(Predicted)
Density:1.338±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

ACY-957 99.91% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

There total 6 articles about N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1609390-66-0
C₃₄H₃₉N₅O₅S

: 1609389-52-7
N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 849807-09-6
2-chloro-quinoline-6-carboxylic acid methyl ester

: 1609389-52-7
N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 100 °C

2: ethanol; sodium hydroxide / tetrahydrofuran / 4 h / 70 °C

3: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 55 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; ethanol; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1609389-71-0
methyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoline-6-carboxylate

: 1609389-52-7
N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; sodium hydroxide / tetrahydrofuran / 4 h / 70 °C

2: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 55 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; ethanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;