N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester
• CAS No.: 237753-46-7
• Molecular Formula: C₃₈H₅₅N₃O₁₆
• Molecular Weight: 809.865

Synonyms:N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Chemical Property of N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

There total 1 articles about N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

H-Aib-Aib-O(t-Bu) (83537-95-5) + (2S,3R)-2-Benzyloxycarbonylamino-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-butyric acid → N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester (237753-46-7)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(01)00098-9

Reference yield:

N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester (237753-46-7) → 2-{2-[(2S,3R)-2-Benzyloxycarbonylamino-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-2-methyl-propionylamino}-2-methyl-propionic acid

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(01)00098-9

Reference yield:

N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester (237753-46-7) → N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyryl-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 0.13 g / aq. TFA / 1 h / 20 °C

2: 62 percent / HATU; DIEA / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)00098-9

upstream raw materials:

H-Aib-Aib-O(t-Bu)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 237753-46-7 N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-L-threonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send