(E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate

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Chemical Name:(E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate
CAS No.:891828-13-0
Molecular Formula:C₃₀H₄₁NO₆Si
Molecular Weight:539.744
Hs Code.:

Synonyms:(E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate

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Chemical Property of (E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate

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Technology Process of (E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate

There total 6 articles about (E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 891827-76-2
(E)-((5-bromopent-2-en-1-yl)oxy)(tert-butyl)diphenylsilane

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 891828-13-0
(E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

(E)-((5-bromopent-2-en-1-yl)oxy)(tert-butyl)diphenylsilane; In N,N-dimethyl-formamide; at 90 ℃; for 3h;
DOI:10.1016/j.tet.2006.02.073

Reference yield:

: 891827-75-1
toluene-4-sulfonic acid 5-(tert-butyl-diphenyl-silanyloxy)-pent-3-enyl ester

: 891828-13-0
(E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2.48 g / KBr / dimethylformamide / 0.58 h / 100 °C

2.1: NaH / dimethylformamide / 0 - 20 °C

2.2: 88 percent / dimethylformamide / 3 h / 90 °C

With sodium hydride; potassium bromide; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.02.073

Reference yield:

: 891827-74-0
(E)-1-[(tert-butyldiphenylsilyl)oxy-5-(4-methoxybenzyl)oxy]pent-2-ene

: 891828-13-0
(E)-diethyl 2-acetamido-2-{5-[(tert-butyldiphenylsilyl)oxy]pent-3-enyl}malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; water / CH₂Cl₂ / 1.17 h / 20 °C

2.1: pyridine / 1.75 h / 20 °C

3.1: 2.48 g / KBr / dimethylformamide / 0.58 h / 100 °C

4.1: NaH / dimethylformamide / 0 - 20 °C

4.2: 88 percent / dimethylformamide / 3 h / 90 °C

With pyridine; water; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium bromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.02.073