Technology Process of (2R,8R,20R)-2-benzyloxy-22-(tert-butyldiphenylsilanyloxy)-20-(4-methoxybenzyloxy)docosan-8-ol
There total 16 articles about (2R,8R,20R)-2-benzyloxy-22-(tert-butyldiphenylsilanyloxy)-20-(4-methoxybenzyloxy)docosan-8-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Wilkinson's catalyst; hydrogen;
In
benzene;
at 20 ℃;
for 10h;
DOI:10.1021/jo0496392
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 94 percent / LiAlH4 / diethyl ether / 2 h / 0 °C
2.1: 77 percent / pyrdine / 3 h / 0 °C
3.1: magnesium / tetrahydrofuran
3.2: tetrahydrofuran / 0.5 h / 0 °C
3.3: 12.8 g / CuI / tetrahydrofuran / 15 h / 0 - 50 °C
4.1: 87 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 24 h / 0 - 20 °C
5.1: 44 percent / (R,R)-1,2-cyclohexanediamine based salen cobalt complex; acetic acid / toluene / 1 h / 20 °C
6.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
6.2: 91 percent / BF3*Et2O / tetrahydrofuran; hexane / 1.5 h / -78 °C
7.1: 99 percent / tris(triphenylphosphine)rhodium chloride; H2 / benzene / 10 h / 20 °C
With
pyridine; Wilkinson's catalyst; lithium aluminium tetrahydride; n-butyllithium; (R,R)-1,2-cyclohexanediamine based salen cobalt; hydrogen; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; benzene;
DOI:10.1021/jo0496392
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 77 percent / pyrdine / 3 h / 0 °C
2.1: magnesium / tetrahydrofuran
2.2: tetrahydrofuran / 0.5 h / 0 °C
2.3: 12.8 g / CuI / tetrahydrofuran / 15 h / 0 - 50 °C
3.1: 87 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 24 h / 0 - 20 °C
4.1: 44 percent / (R,R)-1,2-cyclohexanediamine based salen cobalt complex; acetic acid / toluene / 1 h / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
5.2: 91 percent / BF3*Et2O / tetrahydrofuran; hexane / 1.5 h / -78 °C
6.1: 99 percent / tris(triphenylphosphine)rhodium chloride; H2 / benzene / 10 h / 20 °C
With
pyridine; Wilkinson's catalyst; n-butyllithium; (R,R)-1,2-cyclohexanediamine based salen cobalt; hydrogen; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; hexane; dichloromethane; toluene; benzene;
DOI:10.1021/jo0496392
