2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide

Base Information

• Chemical Name: 2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide
• CAS No.: 183070-49-7
• Molecular Formula: C₁₉H₁₉NO₃
• Molecular Weight: 309.365
• Mol file: 183070-49-7.mol

Synonyms:2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide

Chemical Property of 2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide

There total 2 articles about 2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroxy-3-methoxyphenyl acetic acid chloride (89652-37-9) + (1H-indene-3-yl)methylammonium chloride → 2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide (183070-49-7)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane;

DOI:10.1016/0040-4039(96)01642-5

Reference yield:

inden-1-one (83-33-0) → 2-(4-Hydroxy-3-methoxy-phenyl)-N-(3H-inden-1-ylmethyl)-acetamide (183070-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LiCN; 2.) LiAlH₄; 3.) 2M HCl / 1.) THF, rt., 20 h; 2.) THF, heating; 3.) MeOH

2: 100 percent / NaHCO₃ / CH₂Cl₂

With hydrogenchloride; lithium aluminium tetrahydride; lithium cyanide; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1016/0040-4039(96)01642-5

upstream raw materials:

4-hydroxy-3-methoxyphenyl acetic acid chloride

inden-1-one