(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid

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Chemical Name:(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid
CAS No.:119706-37-5
Molecular Formula:C₂HF₃O₂*C₃₀H₃₅N₃O₄
Molecular Weight:615.65
Hs Code.:

Synonyms:(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid

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Chemical Property of (S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid

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Technology Process of (S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid

There total 3 articles about (S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 119706-37-5
(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 1,8-diazabicyclo<5,4,0>-undec-7-en / benzene / 1 h / Heating

2: 90 percent / BOP, DIEA / dimethylformamide / 0.5 h / Ambient temperature

3: 0.5 h / Ambient temperature

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)86014-2

Reference yield:

: 119706-10-4
BOC-Leu-OBg

: 119706-37-5
(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / BOP, DIEA / dimethylformamide / 0.5 h / Ambient temperature

2: 0.5 h / Ambient temperature

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86014-2