C₂₀H₂₀N₄O₄

Base Information

• Chemical Name: C₂₀H₂₀N₄O₄
• CAS No.: 1408083-60-2
• Molecular Formula: C₂₀H₂₀N₄O₄
• Molecular Weight: 380.403
• Mol file: 1408083-60-2.mol

Synonyms:C₂₀H₂₀N₄O₄

Chemical Property of C₂₀H₂₀N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₀N₄O₄

There total 5 articles about C₂₀H₂₀N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 5-(2-((tert-butoxycarbonyl)amino)acetamido)-1H-indole-3-carboxylate (1425676-96-5) + p-Tolylisocyanate (622-58-2,374675-64-6) → C20H20N4O4 (1408083-60-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm301097p

Reference yield:

methyl 5-nitro-1H-indole-3-carboxylate (686747-51-3) → C20H20N4O4 (1408083-60-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / 760.05 Torr

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm301097p

Reference yield:

5-nitro-1H-indole-3-carbonyl chloride (1058740-61-6) → C20H20N4O4 (1408083-60-2)

Guidance literature:

Multi-step reaction with 5 steps

1: dihydrogen peroxide / water / 4 h / Reflux

2: sulfuric acid / 6 h / Reflux

3: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / 760.05 Torr

4: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C / Inert atmosphere

5: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With sulfuric acid; 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm301097p

upstream raw materials:

methyl 5-nitro-1H-indole-3-carboxylate

methyl 5-amino-1H-indole-3-carboxylate

ethyl 5-(2-((tert-butoxycarbonyl)amino)acetamido)-1H-indole-3-carboxylate

p-Tolylisocyanate