Technology Process of (Z)-2,3,4-tribenzylpenta-2,4-dien-1-ol
There total 5 articles about (Z)-2,3,4-tribenzylpenta-2,4-dien-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane;
at -78 ℃;
for 3h;
DOI:10.1002/anie.201307835
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / benzene; N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C
1.2: 54 h / 85 °C
2.1: lithium hydroxide / hexane / 0.17 h / 0 °C
2.2: 1 h / 0 °C
3.1: tetrakis(triphenylphosphine) palladium(0); copper(l) chloride; lithium chloride / dimethyl sulfoxide / 11 h / 0 - 80 °C
4.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 3 h / -78 °C
With
tetrakis(triphenylphosphine) palladium(0); sodium hydride; diisobutylaluminium hydride; copper(l) chloride; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
3.1: |Stille Cross Coupling / 4.1: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/anie.201307835
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ethylmagnesium bromide / tetrahydrofuran / 3 h / 0 - 20 °C
2: tris(pentafluorophenyl)borate / toluene / 1 h / 0 °C
3: tetrakis(triphenylphosphine) palladium(0); copper(l) chloride; lithium chloride / dimethyl sulfoxide / 11 h / 0 - 80 °C
4: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 3 h / -78 °C
With
tetrakis(triphenylphosphine) palladium(0); tris(pentafluorophenyl)borate; ethylmagnesium bromide; diisobutylaluminium hydride; copper(l) chloride; lithium chloride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
3: |Stille Cross Coupling / 4: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/anie.201307835
