(5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride

Base Information

Chemical Name:(5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride
CAS No.:1340584-77-1
Molecular Formula:C₁₉H₂₆N₄O₇S*ClH
Molecular Weight:490.965
Hs Code.:

Synonyms:(5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride

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Chemical Property of (5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride

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Technology Process of (5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride

There total 5 articles about (5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1340584-76-0
C₂₄H₃₄N₄O₉S

: 1340584-77-1
(5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; for 0.5h;
DOI:10.1039/c1ob05740e

Reference yield:

: {2-amino-3-[2-amino-2-(methoxycarbonylmethylcarbamoyl)ethyldisulfanyl]propionylamino}acetic acid methyl ester dihydrochloride

: 1340584-77-1
(5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / tetrahydrofuran; N,N-dimethyl-formamide / -10 - 20 °C / Inert atmosphere

2: tributylphosphine; water / methanol / 2 h / 20 °C / Inert atmosphere

3: triethylamine / acetonitrile / 3 h / 20 °C

4: hydrogenchloride / methanol / 0.5 h

With 4-methyl-morpholine; hydrogenchloride; tributylphosphine; water; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c1ob05740e

Reference yield:

: 1340584-73-7
(9R,9'R)-dimethyl 9,9'-(disulfanediylbis(methylene))bis(2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate)

: 1340584-77-1
(5S,9R)-methyl 9-(2-aminoacetamido)-5-methyl-3,6,10-trioxo-1-phenyl-2-oxa-7-thia-4,11-diazatridecan-13-oate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tributylphosphine; water / methanol / 2 h / 20 °C / Inert atmosphere

2: triethylamine / acetonitrile / 3 h / 20 °C

3: hydrogenchloride / methanol / 0.5 h

With hydrogenchloride; tributylphosphine; water; triethylamine; In methanol; acetonitrile;
DOI:10.1039/c1ob05740e